The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
نویسندگان
چکیده
منابع مشابه
macroH2A1 histone variant represses rDNA transcription
The regulation of ribosomal DNA transcription is an important step for the control of cell growth. Epigenetic marks such as DNA methylation and posttranslational modifications of canonical histones have been involved in this regulation, but much less is known about the role of histone variants. In this work, we show that the histone variant macroH2A1 is present on the promoter of methylated rDN...
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Alternative pre-mRNA splicing is a key mechanism for increasing proteomic diversity and modulating gene expression. Emerging evidence indicated that the splicing program is frequently dysregulated during tumorigenesis. Cancer cells produce protein isoforms that can promote growth and survival. The RNA-binding protein QKI5 is a critical regulator of alternative splicing in expanding lists of pri...
متن کاملQKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation.
The histone variant macroH2A1 contains a carboxyl-terminal ∼30-kDa domain called a macro domain. MacroH2A1 is produced as one of two alternatively spliced forms, macroH2A1.1 and macroH2A1.2. While the macro domain of macroH2A1.1 can interact with NAD(+)-derived small molecules, such as poly(ADP-ribose), macroH2A1.2's macro domain cannot. Here, we show that changes in the alternative splicing of...
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چکیده ندارد.
Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome.
We studied the enrichment and distribution of the histone variant mH2A1 in the condensed inactive X (Xi) chromosome. By using highly specific antibodies against mH2A1 and stable HEK 293 cell lines expressing either green fluorescent protein (GFP)-mH2A1 or GFP-H2A, we found that the Xi chromosome contains approximately 1.5-fold more mH2A1 than the autosomes. To determine the in vivo distribution...
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2018
ISSN: 2372-3556
DOI: 10.1080/23723556.2018.1441629